학술논문
Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease
Document Type
article
Author
Sebastian Schmidt; Malte D. Luecken; Dietrich Trümbach; Sina Hembach; Kristina M. Niedermeier; Nicole Wenck; Klaus Pflügler; Constantin Stautner; Anika Böttcher; Heiko Lickert; Ciro Ramirez-Suastegui; Ruhel Ahmad; Michael J. Ziller; Julia C. Fitzgerald; Viktoria Ruf; Wilma D. J. van de Berg; Allert J. Jonker; Thomas Gasser; Beate Winner; Jürgen Winkler; Daniela M. Vogt Weisenhorn; Florian Giesert; Fabian J. Theis; Wolfgang Wurst
Source
Nature Communications, Vol 13, Iss 1, Pp 1-25 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Here, the authors reveal using single-cell RNA sequencing that Parkinson’s disease (PD) patient-derived neuronal cells show altered primary cilia morphology and signaling suggesting cilia dysfunction may underlie PD pathogenesis.