학술논문
Adrenal tropism of SARS-CoV-2 and adrenal findings in a post-mortem case series of patients with severe fatal COVID-19
Document Type
article
Author
Tanja Paul; Stephan Ledderose; Harald Bartsch; Na Sun; Sarah Soliman; Bruno Märkl; Viktoria Ruf; Jochen Herms; Marcel Stern; Oliver T. Keppler; Claire Delbridge; Susanna Müller; Guido Piontek; Yuki Schneider Kimoto; Franziska Schreiber; Tracy Ann Williams; Jens Neumann; Thomas Knösel; Heiko Schulz; Ria Spallek; Matthias Graw; Thomas Kirchner; Axel Walch; Martina Rudelius
Source
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Progressive respiratory failure is the primary cause of death in patients with COVID-19, but pathologies in other tissues may also occur. Here the authors report that adrenal tropism of SARS-CoV-2 is associated with adrenalitis, reduced adrenal cortisol levels and severe adrenal damage in a post-mortem case series of patients with severe fatal COVID-19.