학술논문
Immune Tolerance Induction (ITI) with a pdFVIII/VWF Concentrate (octanate) in 100 Patients in the Observational ITI (ObsITI) Study
Document Type
article
Author
Carmen Escuriola Ettingshausen; Vladimír Vdovin; Nadezhda Zozulya; Pavel Svirin; Tatiana Andreeva; Majda Benedik-Dolničar; Victor Jiménez-Yuste; Lidija Kitanovski; Silva Zupancic-Šalek; Anna Pavlova; Angelika Bátorová; Cesar Montaño Mejía; Gulnara Abdilova; Sigurd Knaub; Martina Jansen; Shannely Lowndes; Larisa Belyanskaya; Olaf Walter; Johannes Oldenburg
Source
TH Open, Vol 06, Iss 02, Pp e124-e134 (2022)
Subject
Language
English
ISSN
2512-9465
Abstract
Background Immune tolerance induction (ITI) with repeated factor VIII (FVIII) administration is the only strategy proven to eradicate inhibitors. The observational ITI study is evaluating ITI with a range of FVIII products. Methods This subgroup analysis reports prospective interim data for patients treated with a plasma-derived, von Willebrand factor-stabilized FVIII concentrate (pdFVIII/VWF, octanate). Complete success (CS) of ITI required achievement of three criteria: inhibitor titer