학술논문
Clonal evolution patterns in acute myeloid leukemia with NPM1 mutation
Document Type
article
Author
Sibylle Cocciardi; Anna Dolnik; Silke Kapp-Schwoerer; Frank G. Rücker; Susanne Lux; Tamara J. Blätte; Sabrina Skambraks; Jan Krönke; Florian H. Heidel; Tina M. Schnöder; Andrea Corbacioglu; Verena I. Gaidzik; Peter Paschka; Veronica Teleanu; Gudrun Göhring; Felicitas Thol; Michael Heuser; Arnold Ganser; Daniela Weber; Eric Sträng; Hans A. Kestler; Hartmut Döhner; Lars Bullinger; Konstanze Döhner
Source
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
NPM1 gene mutation is a founding event in acute myeloid leukaemia. Here, the authors find that at relapse, some patients lose the NPM1 mutation and show distinct mutational and gene expression patterns, highlighting a potential route for relapse.