학술논문
Proteins from SARS-CoV-2 reduce T cell proliferation: A mirror image of sepsis
Document Type
article
Author
Source
Heliyon, Vol 6, Iss 12, Pp e05635- (2020)
Subject
Language
English
ISSN
2405-8440
Abstract
Increased cytokine levels, acute phase reactants and immune checkpoint expression changes have been described in patients with Coronavirus Disease 2019 (COVID-19). Here, we have reported a monocyte polarization towards a low HLA-DR and high PD-L1 expression after long exposure to proteins from SARS-CoV-2. Moreover, CD86 expression was also reduced over SARS-CoV-2 proteins exposure. Additionally, T-cells proliferation was significantly reduced after stimulation with these proteins. Eventually, patients with long-term SARS-CoV-2 infection also exhibited a significant blockade of T-cells proliferation.