학술논문
SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling
Document Type
article
Author
Scott B. Biering; Francielle Tramontini Gomes de Sousa; Laurentia V. Tjang; Felix Pahmeier; Chi Zhu; Richard Ruan; Sophie F. Blanc; Trishna S. Patel; Caroline M. Worthington; Dustin R. Glasner; Bryan Castillo-Rojas; Venice Servellita; Nicholas T. N. Lo; Marcus P. Wong; Colin M. Warnes; Daniel R. Sandoval; Thomas Mandel Clausen; Yale A. Santos; Douglas M. Fox; Victoria Ortega; Anders M. Näär; Ralph S. Baric; Sarah A. Stanley; Hector C. Aguilar; Jeffrey D. Esko; Charles Y. Chiu; John E. Pak; P. Robert Beatty; Eva Harris
Source
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Severe COVID-19 is associated with epithelial and endothelial barrier dysfunction, however, the molecular pathways resulting in endothelial barrier dysfunction and vascular leakage are only sparsely understood. Here, Biering et al. show that SARS-CoV-2 spike protein is sufficient to induce barrier dysfunction and vascular leak. They show a role for integrins, TGF-beta, ECM remodeling enzymes, and glycosaminoglycans in this S-mediated barrier dysfunction.