학술논문
PD-L1 and ICOSL discriminate human Secretory and Helper dendritic cells in cancer, allergy and autoimmunity
Document Type
article
Author
Caroline Hoffmann; Floriane Noel; Maximilien Grandclaudon; Lucile Massenet-Regad; Paula Michea; Philemon Sirven; Lilith Faucheux; Aurore Surun; Olivier Lantz; Mylene Bohec; Jian Ye; Weihua Guo; Juliette Rochefort; Jerzy Klijanienko; Sylvain Baulande; Charlotte Lecerf; Maud Kamal; Christophe Le Tourneau; Maude Guillot-Delost; Vassili Soumelis
Source
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Phenotypic and functional states of dendritic cells critically influence the outcome of cancer and inflammation. Authors here show by single cell transcriptomics and in vitro validation assays that dichotomous PD-L1 and ICOSL expression assign dendritic cells to secretory and helper functions, with respective predominance of inflammatory cytokine expression or T helper cytokine induction.