학술논문
Circulating miR-184 is a potential predictive biomarker of cardiac damage in Anderson–Fabry disease
Document Type
article
Author
Irene Salamon; Elena Biagini; Paolo Kunderfranco; Roberta Roncarati; Manuela Ferracin; Nevio Taglieri; Elena Nardi; Noemi Laprovitera; Luciana Tomasi; Marisa Santostefano; Raffaello Ditaranto; Giovanni Vitale; Elena Cavarretta; Antonio Pisani; Eleonora Riccio; Valeria Aiello; Irene Capelli; Gaetano La Manna; Nazzareno Galiè; Letizia Spinelli; Gianluigi Condorelli
Source
Cell Death and Disease, Vol 12, Iss 12, Pp 1-7 (2021)
Subject
Language
English
ISSN
2041-4889
Abstract
Abstract Enzyme replacement therapy (ERT) is a mainstay of treatment for Anderson–Fabry disease (AFD), a pathology with negative effects on the heart and kidneys. However, no reliable biomarkers are available to monitor its efficacy. Therefore, we tested a panel of four microRNAs linked with cardiac and renal damage in order to identify a novel biomarker associated with AFD and modulated by ERT. To this end, 60 patients with a definite diagnosis of AFD and on chronic ERT, and 29 age- and sex-matched healthy individuals, were enrolled by two Italian university hospitals. Only miR-184 met both conditions: its level discriminated untreated AFD patients from healthy individuals (c-statistic = 0.7522), and it was upregulated upon ERT (P