학술논문
Presence of specific SARS-COV2 antibodies in hemodialysis patients and their caregivers after the first wave of COVID-19
Document Type
article
Author
Thomas Robert; Guillaume Lano; Noémie Resseguier; Mickaël Bobot; Dammar Bouchouareb; Stéphane Burtey; Xavier de Lamballerie; Jean Dhorne; Bertrand Dussol; Ariane Duval; Julien Faraut; Toscane Fourié; Philippe Giaime; Mourad Hallah; Dominique Jaubert; Océane Jéhel; Tristan Legris; Stéphane Liotatis; Valérie Moal; Laetitia Ninove; Nathalie Pedinielli; Marion Pelletier; Manon Romeu-Giannoli; Mariela Saba; Marion Sallée; Laurent Samson; Adriana Saveanu; Violaine Scarfoglière; Pascale Sebahoun; Romain Vial; Clarissa Von Kotze; Philippe Brunet; Gaëtan Lebrun; Stanislas Bataille; Noémie Jourde-Chiche
Source
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Subject
Language
English
ISSN
2045-2322
Abstract
Abstract Hemodialysis (HD) patients are at risk for severe COVID-19 and cannot comply with social distancing. SARS-COV2 seroprevalence in French patients and caregivers after the first wave of COVID-19 is unknown. SeroCOVIDial is a prospective study conducted between June and December 2020. SARS-COV2 seroprevalence was evaluated by a rapid serological test (BIOSYNEX) in HD patients and caregivers, and the presence or not of anti-SARS-COV2 neutralizing or non-neutralizing antibodies in patients was also determined by ELISA and seroneutralization. In June 2020, 451 HD patients and 238 caregivers were included. Overall SARS-COV2 seroprevalence was 8.4% (patients) and 6.7% (caregivers), and was 87.1% (patients) and 90.0% (caregivers) in participants with a previously documented SARS-COV2 infection. Overall seroprevalence reached 13.8% (patients) and 12.6% (caregivers) following the second epidemic wave. During the follow-up, 38 (8.4%) patients died (9 of COVID-19). Among the 44 (10.6%) patients who became infected, only two were seropositive at M0. The levels of anti-SARS-COV2 antibodies decreased over time in patients and caregivers. The BIOSYNEX test showed 82.9% sensitivity and 97.7% specificity. Prevalence of anti-SARS-COV2 antibodies was low in HD patients and caregivers after the first epidemic wave but rose after the second wave. A rapid serological test showed good performances and could be useful for future monitoring of anti-SARS-COV2 antibodies.