학술논문
Modeling the longitudinal changes of ancestry diversity in the Million Veteran Program
Document Type
article
Author
Frank R. Wendt; Gita A. Pathak; Jacqueline Vahey; Xuejun Qin; Dora Koller; Brenda Cabrera-Mendoza; Angela Haeny; Kelly M. Harrington; Nallakkandi Rajeevan; Linh M. Duong; Daniel F. Levey; Flavio De Angelis; Antonella De Lillo; Tim B. Bigdeli; Saiju Pyarajan; VA Million Veteran Program; John Michael Gaziano; Joel Gelernter; Mihaela Aslan; Dawn Provenzale; Drew A. Helmer; Elizabeth R. Hauser; Renato Polimanti; Department of Veteran Affairs Cooperative Study Program (#2006)
Source
Human Genomics, Vol 17, Iss 1, Pp 1-11 (2023)
Subject
Language
English
ISSN
1479-7364
Abstract
Abstract Background The Million Veteran Program (MVP) participants represent 100 years of US history, including significant social and demographic changes over time. Our study assessed two aspects of the MVP: (i) longitudinal changes in population diversity and (ii) how these changes can be accounted for in genome-wide association studies (GWAS). To investigate these aspects, we divided MVP participants into five birth cohorts (N-range = 123,888 [born from 1943 to 1947] to 136,699 [born from 1948 to 1953]). Results Ancestry groups were defined by (i) HARE (harmonized ancestry and race/ethnicity) and (ii) a random-forest clustering approach using the 1000 Genomes Project and the Human Genome Diversity Project (1kGP + HGDP) reference panels (77 world populations representing six continental groups). In these groups, we performed GWASs of height, a trait potentially affected by population stratification. Birth cohorts demonstrate important trends in ancestry diversity over time. More recent HARE-assigned Europeans, Africans, and Hispanics had lower European ancestry proportions than older birth cohorts (0.010