학술논문
Genetic architecture of heart failure with preserved versus reduced ejection fraction
Document Type
article
Author
Jacob Joseph; Chang Liu; Qin Hui; Krishna Aragam; Zeyuan Wang; Brian Charest; Jennifer E. Huffman; Jacob M. Keaton; Todd L. Edwards; Serkalem Demissie; Luc Djousse; Juan P. Casas; J. Michael Gaziano; Kelly Cho; Peter W. F. Wilson; Lawrence S. Phillips; VA Million Veteran Program; Christopher J. O’Donnell; Yan V. Sun
Source
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
While the genetic basis of heart failure has been explored by genetic studies, the differences between subtypes are not well understood. Here, the authors performed genetic analyses on the two major subtypes of heart failure in a large biobank with genetic and health record data, finding unique genetic architecture for each subtype.