학술논문
Transfer of thawed frozen embryo versus fresh embryo to improve the healthy baby rate in women undergoing IVF: the E-Freeze RCT
Document Type
article
Author
Abha Maheshwari; Vasha Bari; Jennifer L Bell; Siladitya Bhattacharya; Priya Bhide; Ursula Bowler; Daniel Brison; Tim Child; Huey Yi Chong; Ying Cheong; Christina Cole; Arri Coomarasamy; Rachel Cutting; Fiona Goodgame; Pollyanna Hardy; Haitham Hamoda; Edmund Juszczak; Yacoub Khalaf; Andrew King; Jennifer J Kurinczuk; Stuart Lavery; Clare Lewis-Jones; Louise Linsell; Nick Macklon; Raj Mathur; David Murray; Jyotsna Pundir; Nick Raine-Fenning; Madhurima Rajkohwa; Lynne Robinson; Graham Scotland; Kayleigh Stanbury; Stephen Troup
Source
Health Technology Assessment, Vol 26, Iss 25 (2022)
Subject
Language
English
ISSN
1366-5278
2046-4924
2046-4924
Abstract
Background: Freezing all embryos, followed by thawing and transferring them into the uterine cavity at a later stage (freeze-all), instead of fresh-embryo transfer may lead to improved pregnancy rates and fewer complications during in vitro fertilisation and pregnancies resulting from it. Objective: We aimed to evaluate if a policy of freeze-all results in a higher healthy baby rate than the current policy of transferring fresh embryos. Design: This was a pragmatic, multicentre, two-arm, parallel-group, non-blinded, randomised controlled trial. Setting: Eighteen in vitro fertilisation clinics across the UK participated from February 2016 to April 2019. Participants: Couples undergoing their first, second or third cycle of in vitro fertilisation treatment in which the female partner was aged