학술논문
Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer
Document Type
article
Author
Maik Luu; Zeno Riester; Adrian Baldrich; Nicole Reichardt; Samantha Yuille; Alessandro Busetti; Matthias Klein; Anne Wempe; Hanna Leister; Hartmann Raifer; Felix Picard; Khalid Muhammad; Kim Ohl; Rossana Romero; Florence Fischer; Christian A. Bauer; Magdalena Huber; Thomas M. Gress; Matthias Lauth; Sophia Danhof; Tobias Bopp; Thomas Nerreter; Imke E. Mulder; Ulrich Steinhoff; Michael Hudecek; Alexander Visekruna
Source
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
The activity of immune cells can be regulated by the microbiome. Here, the authors show that the fatty acids pentanoate and butyrate—normally released by the microbiome—increase the anti-tumour activity of cytotoxic T lymphocytes and chimeric antigen receptor T cells through metabolic and epigenetic reprogramming.