학술논문
The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes
Document Type
article
Author
Maik Luu; Sabine Pautz; Vanessa Kohl; Rajeev Singh; Rossana Romero; Sébastien Lucas; Jörg Hofmann; Hartmann Raifer; Niyati Vachharajani; Lucia Campos Carrascosa; Boris Lamp; Andrea Nist; Thorsten Stiewe; Yoav Shaul; Till Adhikary; Mario M. Zaiss; Matthias Lauth; Ulrich Steinhoff; Alexander Visekruna
Source
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
Short-chain fatty acids (SCFAs) have immunomodulatory effects, but the underlying mechanisms are still unclear. Here the authors show that a SCFA, pentanoate, suppresses autoimmune inflammation in mouse models of colitis and multiple sclerosis via epigenetic modulation of immune cell metabolic and functional pathways.