학술논문
Generation of eight human induced pluripotent stem cell lines from Parkinson's disease patients carrying familial mutations
Document Type
article
Author
Source
Stem Cell Research, Vol 42, Iss , Pp - (2020)
Subject
Language
English
ISSN
1873-5061
Abstract
We generated eight induced pluripotent stem cell (iPSC) lines from Parkinson's disease (PD) patients with different familial mutations using non-integrating episomal plasmids. All iPSC lines have a normal karyotype, express pluripotent genes including POU5F1, NANOG, and show alkaline phosphatase activity, as well as the ability to differentiate into all three germ layers. These PD iPSC lines can be used for disease modeling to identify PD mechanisms and for the development or stratification of new drugs.