학술논문
Impact of Varicocele Repair on Semen Parameters in Infertile Men: A Systematic Review and Meta-Analysis
Document Type
article
Author
Rossella Cannarella; Ramadan Saleh; Florence Boitrelle; Murat Gül; Tuncay Toprak; Gianmaria Salvio; Mohamed Arafa; Giorgio I. Russo; Ahmed M. Harraz; Rajender Singh; Nicolas Garrido; Taha Abo-Almagd Abdel-Meguid Hamoda; Amarnath Rambhatla; Parviz Kavoussi; Shinnosuke Kuroda; Gökhan Çalik; Pallavi Saini; Erman Ceyhan; Fotios Dimitriadis; Ralf Henkel; Andrea Crafa; Ayad Palani; Mesut Berkan Duran; Evangelos Maziotis; Émine Saïs; Marion Bendayan; Mahsa Darbandi; Tan V. Le; Sezgin Gunes; Petroula Tsioulou; Pallav Sengupta; Berk Hazir; Gökhan Çeker; Sara Darbandi; Damayanthi Durairajanayagam; Azin Aghamajidi; Noora Alkhalidi; Emrullah Sogutdelen; Kristian Leisegang; Abdullah Alarbid; Christopher C. K. Ho; Vineet Malhotra; Federica Finocchi; Luís Crisóstomo; Raghavender Kosgi; Haitham ElBardisi; Armand Zini; Ponco Birowo; Giovanni Colpi; Hyun Jun Park; Ege Can Serefoglu; Quang Nguyen; Edmund Ko; Jean de la Rosette; Germar M. Pinggera; Ho Vinh Phuoc Nguyen; Hussein Kandil; Rupin Shah
Source
The World Journal of Men's Health, Vol 41, Iss 2, Pp 289-310 (2023)
Subject
Language
English
ISSN
2287-4208
2287-4690
2287-4690
Abstract
Purpose: Despite the significant role of varicocele in the pathogenesis of male infertility, the impact of varicocele repair (VR) on conventional semen parameters remains controversial. Only a few systematic reviews and meta-analyses (SRMAs) have evaluated the impact of VR on sperm concentration, total motility, and progressive motility, mostly using a before-after analytic approach. No SRMA to date has evaluated the change in conventional semen parameters after VR compared to untreated controls. This study aimed to evaluate the effect of VR on conventional semen parameters in infertile patients with clinical varicocele compared to untreated controls. Materials and Methods: A literature search was performed using Scopus, PubMed, Embase, and Cochrane databases following the Population Intervention Comparison Outcome (PICOS) model (Population: infertile patients with clinical varicocele; Intervention: VR [any technique]; Comparison: infertile patients with clinical varicocele that were untreated; Outcome: sperm concentration, sperm total count, progressive sperm motility, total sperm motility, sperm morphology, and semen volume; Study type: randomized controlled trials and observational studies). Results: A total of 1,632 abstracts were initially assessed for eligibility. Sixteen studies were finally included with a total of 2,420 infertile men with clinical varicocele (1,424 patients treated with VR vs. 996 untreated controls). The analysis showed significantly improved post-operative semen parameters in patients compared to controls with regards to sperm concentration (standardized mean difference [SMD] 1.739; 95% CI 1.129 to 2.349; p