학술논문
Megahertz pulse trains enable multi-hit serial femtosecond crystallography experiments at X-ray free electron lasers
Document Type
article
Author
Susannah Holmes; Henry J. Kirkwood; Richard Bean; Klaus Giewekemeyer; Andrew V. Martin; Marjan Hadian-Jazi; Max O. Wiedorn; Dominik Oberthür; Hugh Marman; Luigi Adriano; Nasser Al-Qudami; Saša Bajt; Imrich Barák; Sadia Bari; Johan Bielecki; Sandor Brockhauser; Mathew A. Coleman; Francisco Cruz-Mazo; Cyril Danilevski; Katerina Dörner; Alfonso M. Gañán-Calvo; Rita Graceffa; Hans Fanghor; Michael Heymann; Matthias Frank; Alexander Kaukher; Yoonhee Kim; Bostjan Kobe; Juraj Knoška; Torsten Laurus; Romain Letrun; Luis Maia; Marc Messerschmidt; Markus Metz; Thomas Michelat; Grant Mills; Serguei Molodtsov; Diana C. F. Monteiro; Andrew J. Morgan; Astrid Münnich; Gisel E. Peña Murillo; Gianpietro Previtali; Adam Round; Tokushi Sato; Robin Schubert; Joachim Schulz; Megan Shelby; Carolin Seuring; Jonas A. Sellberg; Marcin Sikorski; Alessandro Silenzi; Stephan Stern; Jola Sztuk-Dambietz; Janusz Szuba; Martin Trebbin; Patrick Vagovic; Thomas Ve; Britta Weinhausen; Krzysztof Wrona; Paul Lourdu Xavier; Chen Xu; Oleksandr Yefanov; Keith A. Nugent; Henry N. Chapman; Adrian P. Mancuso; Anton Barty; Brian Abbey; Connie Darmanin
Source
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Free-electron lasers are capable of high repetition rates and it is assumed that protein crystals often do not survive the first X-ray pulse. Here the authors address these issues with a demonstration of multi-hit serial crystallography in which multiple FEL pulses interact with the sample without destroying it.