학술논문
The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors
Document Type
article
Author
Ali Khateb; Anagha Deshpande; Yongmei Feng; Darren Finlay; Joo Sang Lee; Ikrame Lazar; Bertrand Fabre; Yan Li; Yu Fujita; Tongwu Zhang; Jun Yin; Ian Pass; Ido Livneh; Irmela Jeremias; Carol Burian; James R. Mason; Ronit Almog; Nurit Horesh; Yishai Ofran; Kevin Brown; Kristiina Vuori; Michael Jackson; Eytan Ruppin; Aniruddha J. Deshpande; Ze’ev A. Ronai
Source
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Epigenetic changes are implicated in Acute myeloid leukemia (AML) tumorigenesis. Here, the authors show that the ubiquitin ligase RNF5 and its substrate RBBP4 contribute to AML development by regulating epigenetic-controlled transcription which determines AML sensitivity to HDAC inhibitors.