학술논문
Transcriptional profiling of matched patient biopsies clarifies molecular determinants of enzalutamide-induced lineage plasticity
Document Type
article
Author
Thomas C. Westbrook; Xiangnan Guan; Eva Rodansky; Diana Flores; Chia Jen Liu; Aaron M. Udager; Radhika A. Patel; Michael C. Haffner; Ya-Mei Hu; Duanchen Sun; Tomasz M. Beer; Adam Foye; Rahul Aggarwal; David A. Quigley; Jack F. Youngren; Charles J. Ryan; Martin Gleave; Yuzhuo Wang; Jiaoti Huang; Ilsa Coleman; Colm Morrissey; Peter S. Nelson; Christopher P. Evans; Primo Lara; Robert E. Reiter; Owen Witte; Matthew Rettig; Christopher K. Wong; Alana S. Weinstein; Vlado Uzunangelov; Josh M. Stuart; George V. Thomas; Felix Y. Feng; Eric J. Small; Joel A. Yates; Zheng Xia; Joshi J. Alumkal
Source
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Lineage plasticity is increasingly recognized as an emergent resistance mechanism after treatment with androgen receptor signalling inhibitors. To understand determinants of resistance, the authors analyzed the transcriptomes of patient tumor biopsies before enzalutamide treatment and at progression and identified a gene expression program associated with lineage plasticity risk and poor outcomes.