학술논문
Design of a methotrexate-controlled chemical dimerization system and its use in bio-electronic devices
Document Type
article
Author
Source
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Efforts to engineer artificial allosteric systems are ongoing. Here the authors analyse factors influencing development of artificial small molecule:protein complexes that act as chemically induced dimerization (CID) systems; they use one of the CIDs to construct an electrochemical biosensor of methotrexate.