학술논문
Live-cell p53 single-molecule binding is modulated by C-terminal acetylation and correlates with transcriptional activity
Document Type
article
Author
Source
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Subject
Language
English
ISSN
2041-1723
Abstract
Both transcription binding kinetics and post-translational modifications of transcription factors are thought to play a role in the modulation of transcription. Here the authors use single-molecule tracking to directly demonstrate that p53 acetylation modulates promoter residence time and transcriptional activity.