학술논문
Maternal outcomes and risk factors for COVID-19 severity among pregnant women
Document Type
article
Author
Manon Vouga; Guillaume Favre; Oscar Martinez-Perez; Leo Pomar; Laura Forcen Acebal; Alejandra Abascal-Saiz; Maria Rosa Vila Hernandez; Najeh Hcini; Véronique Lambert; Gabriel Carles; Joanna Sichitiu; Laurent Salomon; Julien Stirnemann; Yves Ville; Begoña Martinez de Tejada; Anna Goncé; Ameth Hawkins-Villarreal; Karen Castillo; Eduard Gratacos Solsona; Lucas Trigo; Brian Cleary; Michael Geary; Helena Bartels; Feras Al-Kharouf; Fergal Malone; Mary Higgins; Niamh Keating; Susan Knowles; Christophe Poncelet; Carolina Carvalho Ribeiro-do-Valle; Fernanda Surita; Amanda Dantas-Silva; Carolina Borrelli; Adriana Gomes Luz; Javiera Fuenzalida; Jorge Carvajal; Manuel Guerra Canales; Olivia Hernandez; Olga Grechukhina; Albert I. Ko; Uma Reddy; Rita Figueiredo; Marina Moucho; Pedro Viana Pinto; Carmen De Luca; Marco De Santis; Diogo Ayres de Campos; Inês Martins; Charles Garabedian; Damien Subtil; Betania Bohrer; Maria Lucia Da Rocha Oppermann; Maria Celeste Osorio Wender; Lavinia Schuler-Faccini; Maria Teresa Vieira Sanseverino; Camila Giugliani; Luciana Friedrich; Mariana Horn Scherer; Nicolas Mottet; Guillaume Ducarme; Helene Pelerin; Chloe Moreau; Bénédicte Breton; Thibaud Quibel; Patrick Rozenberg; Eric Giannoni; Cristina Granado; Cécile Monod; Doris Mueller; Irene Hoesli; Dirk Bassler; Sandra Heldstab; Nicole Ochsenbein Kölble; Loïc Sentilhes; Melissa Charvet; Jan Deprest; Jute Richter; Lennart Van der Veeken; Béatrice Eggel-Hort; Gaetan Plantefeve; Mohamed Derouich; Albaro José Nieto Calvache; Maria Camila Lopez-Giron; Juan Manuel Burgos-Luna; Maria Fernanda Escobar-Vidarte; Kurt Hecher; Ann-Christin Tallarek; Eran Hadar; Karina Krajden Haratz; Uri Amikam; Gustavo Malinger; Ron Maymon; Yariv Yogev; Leonhard Schäffer; Arnaud Toussaint; Marie-Claude Rossier; Renato Augusto Moreira De Sa; Claudia Grawe; Karoline Aebi-Popp; Anda-Petronela Radan; Luigi Raio; Daniel Surbek; Paul Böckenhoff; Brigitte Strizek; Martin Kaufmann; Andrea Bloch; Michel Boulvain; Silke Johann; Sandra Andrea Heldstab; Monya Todesco Bernasconi; Gaston Grant; Anis Feki; Anne-Claude Muller Brochut; Marylene Giral; Lucie Sedille; Andrea Papadia; Romina Capoccia Brugger; Brigitte Weber; Tina Fischer; Christian Kahlert; Karin Nielsen Saines; Mary Cambou; Panagiotis Kanellos; Xiang Chen; Mingzhu Yin; Annina Haessig; Sandrine Ackermann; David Baud; Alice Panchaud
Source
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Subject
Language
English
ISSN
2045-2322
Abstract
Abstract Pregnant women may be at higher risk of severe complications associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which may lead to obstetrical complications. We performed a case control study comparing pregnant women with severe coronavirus disease 19 (cases) to pregnant women with a milder form (controls) enrolled in the COVI-Preg international registry cohort between March 24 and July 26, 2020. Risk factors for severity, obstetrical and immediate neonatal outcomes were assessed. A total of 926 pregnant women with a positive test for SARS-CoV-2 were included, among which 92 (9.9%) presented with severe COVID-19 disease. Risk factors for severe maternal outcomes were pulmonary comorbidities [aOR 4.3, 95% CI 1.9–9.5], hypertensive disorders [aOR 2.7, 95% CI 1.0–7.0] and diabetes [aOR2.2, 95% CI 1.1–4.5]. Pregnant women with severe maternal outcomes were at higher risk of caesarean section [70.7% (n = 53/75)], preterm delivery [62.7% (n = 32/51)] and newborns requiring admission to the neonatal intensive care unit [41.3% (n = 31/75)]. In this study, several risk factors for developing severe complications of SARS-CoV-2 infection among pregnant women were identified including pulmonary comorbidities, hypertensive disorders and diabetes. Obstetrical and neonatal outcomes appear to be influenced by the severity of maternal disease.