학술논문
Etiology of oncogenic fusions in 5,190 childhood cancers and its clinical and therapeutic implication
Document Type
article
Author
Yanling Liu; Jonathon Klein; Richa Bajpai; Li Dong; Quang Tran; Pandurang Kolekar; Jenny L. Smith; Rhonda E. Ries; Benjamin J. Huang; Yi-Cheng Wang; Todd A. Alonzo; Liqing Tian; Heather L. Mulder; Timothy I. Shaw; Jing Ma; Michael P. Walsh; Guangchun Song; Tamara Westover; Robert J. Autry; Alexander M. Gout; David A. Wheeler; Shibiao Wan; Gang Wu; Jun J. Yang; William E. Evans; Mignon Loh; John Easton; Jinghui Zhang; Jeffery M. Klco; Soheil Meshinchi; Patrick A. Brown; Shondra M. Pruett-Miller; Xiaotu Ma
Source
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Subject
Language
English
ISSN
2041-1723
Abstract
Oncogenic gene fusions are frequent in childhood cancers but remain poorly understood and untargeted. Here, the authors identify 272 oncogenic fusions in transcriptomics data from 5190 childhood cancer patients, revealing their possible etiologies, their links with tumor progression and evolution, and their potential as therapeutic targets.