학술논문
Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants
Document Type
article
Author
Tokhir Dadaev; Edward J. Saunders; Paul J. Newcombe; Ezequiel Anokian; Daniel A. Leongamornlert; Mark N. Brook; Clara Cieza-Borrella; Martina Mijuskovic; Sarah Wakerell; Ali Amin Al Olama; Fredrick R. Schumacher; Sonja I. Berndt; Sara Benlloch; Mahbubl Ahmed; Chee Goh; Xin Sheng; Zhuo Zhang; Kenneth Muir; Koveela Govindasami; Artitaya Lophatananon; Victoria L. Stevens; Susan M. Gapstur; Brian D. Carter; Catherine M. Tangen; Phyllis Goodman; Ian M. Thompson; Jyotsna Batra; Suzanne Chambers; Leire Moya; Judith Clements; Lisa Horvath; Wayne Tilley; Gail Risbridger; Henrik Gronberg; Markus Aly; Tobias Nordström; Paul Pharoah; Nora Pashayan; Johanna Schleutker; Teuvo L. J. Tammela; Csilla Sipeky; Anssi Auvinen; Demetrius Albanes; Stephanie Weinstein; Alicja Wolk; Niclas Hakansson; Catharine West; Alison M. Dunning; Neil Burnet; Lorelei Mucci; Edward Giovannucci; Gerald Andriole; Olivier Cussenot; Géraldine Cancel-Tassin; Stella Koutros; Laura E. Beane Freeman; Karina Dalsgaard Sorensen; Torben Falck Orntoft; Michael Borre; Lovise Maehle; Eli Marie Grindedal; David E. Neal; Jenny L. Donovan; Freddie C. Hamdy; Richard M. Martin; Ruth C. Travis; Tim J. Key; Robert J. Hamilton; Neil E. Fleshner; Antonio Finelli; Sue Ann Ingles; Mariana C. Stern; Barry Rosenstein; Sarah Kerns; Harry Ostrer; Yong-Jie Lu; Hong-Wei Zhang; Ninghan Feng; Xueying Mao; Xin Guo; Guomin Wang; Zan Sun; Graham G. Giles; Melissa C. Southey; Robert J. MacInnis; Liesel M. FitzGerald; Adam S. Kibel; Bettina F. Drake; Ana Vega; Antonio Gómez-Caamaño; Laura Fachal; Robert Szulkin; Martin Eklund; Manolis Kogevinas; Javier Llorca; Gemma Castaño-Vinyals; Kathryn L. Penney; Meir Stampfer; Jong Y. Park; Thomas A. Sellers; Hui-Yi Lin; Janet L. Stanford; Cezary Cybulski; Dominika Wokolorczyk; Jan Lubinski; Elaine A. Ostrander; Milan S. Geybels; Børge G. Nordestgaard; Sune F. Nielsen; Maren Weisher; Rasmus Bisbjerg; Martin Andreas Røder; Peter Iversen; Hermann Brenner; Katarina Cuk; Bernd Holleczek; Christiane Maier; Manuel Luedeke; Thomas Schnoeller; Jeri Kim; Christopher J. Logothetis; Esther M. John; Manuel R. Teixeira; Paula Paulo; Marta Cardoso; Susan L. Neuhausen; Linda Steele; Yuan Chun Ding; Kim De Ruyck; Gert De Meerleer; Piet Ost; Azad Razack; Jasmine Lim; Soo-Hwang Teo; Daniel W. Lin; Lisa F. Newcomb; Davor Lessel; Marija Gamulin; Tomislav Kulis; Radka Kaneva; Nawaid Usmani; Chavdar Slavov; Vanio Mitev; Matthew Parliament; Sandeep Singhal; Frank Claessens; Steven Joniau; Thomas Van den Broeck; Samantha Larkin; Paul A. Townsend; Claire Aukim-Hastie; Manuela Gago-Dominguez; Jose Esteban Castelao; Maria Elena Martinez; Monique J. Roobol; Guido Jenster; Ron H. N. van Schaik; Florence Menegaux; Thérèse Truong; Yves Akoli Koudou; Jianfeng Xu; Kay-Tee Khaw; Lisa Cannon-Albright; Hardev Pandha; Agnieszka Michael; Andrzej Kierzek; Stephen N. Thibodeau; Shannon K. McDonnell; Daniel J. Schaid; Sara Lindstrom; Constance Turman; Jing Ma; David J. Hunter; Elio Riboli; Afshan Siddiq; Federico Canzian; Laurence N. Kolonel; Loic Le Marchand; Robert N. Hoover; Mitchell J. Machiela; Peter Kraft; The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium; Matthew Freedman; Fredrik Wiklund; Stephen Chanock; Brian E. Henderson; Douglas F. Easton; Christopher A. Haiman; Rosalind A. Eeles; David V. Conti; Zsofia Kote-Jarai
Source
Nature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
Prostate cancer (PrCa) involves a large heritable genetic component. Here, the authors perform multivariate fine-mapping of known PrCa GWAS loci, identifying variants enriched for biological function, explaining more familial relative risk, and with potential application in clinical risk profiling.