학술논문
Sensory innervation in porous endplates by Netrin-1 from osteoclasts mediates PGE2-induced spinal hypersensitivity in mice
Document Type
article
Author
Shuangfei Ni; Zemin Ling; Xiao Wang; Yong Cao; Tianding Wu; Ruoxian Deng; Janet L. Crane; Richard Skolasky; Shadpour Demehri; Gehua Zhen; Amit Jain; Panfeng Wu; Dayu Pan; Bo Hu; Xiao Lyu; Yusheng Li; Hao Chen; Huabin Qi; Yun Guan; Xinzhong Dong; Mei Wan; Xuenong Zou; Hongbin Lu; Jianzhong Hu; Xu Cao
Source
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
Spinal pain is a major clinical problem. Here the authors show that osteoclasts create porous area of endplates of the vertebrae and sensory innervation of porous endplates by Netrin-1 release from osteoclasts mediates PGE2-induced spinal hypersensitivity in mice.