학술논문
Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes
Document Type
article
Author
Rizi Ai; Teresina Laragione; Deepa Hammaker; David L. Boyle; Andre Wildberg; Keisuke Maeshima; Emanuele Palescandolo; Vinod Krishna; David Pocalyko; John W. Whitaker; Yuchen Bai; Sunil Nagpal; Kurtis E. Bachman; Richard I. Ainsworth; Mengchi Wang; Bo Ding; Percio S. Gulko; Wei Wang; Gary S. Firestein
Source
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
Fibroblast-like synoviocytes (FLS) in the intimal layer of the synovium can become invasive and destroy cartilage in patients with rheumatoid arthritis (RA). Here the authors integrate a variety of epigenomic data to map the epigenome of FLS in RA and identify potential therapeutic targets.