학술논문
COVID-19 infected ST-Elevation myocardial infarction in India (COSTA INDIA)
Document Type
article
Author
Abdullakutty Jabir; Geevar Zachariah; Padinhare Purayil Mohanan; Mohit Dayal Gupta; Sivasubramanian Ramakrishnan; Chandra Bhan Meena; L. Sridhar; Meennahalli Palleda Girish; Dipak Ranjan Das; Anshul Gupta; Praveen Nagula; Tom Devasia; Bhavesh Vajifdar; Kamlesh Thakkar; Urmil Shah; Tanuj Bhatia; Smit Srivastava; Sanjeev Sharma; Priya Kubendiran; Pathiyil Balagopalan Jayagopal; Sudeep Kumar; Deepthy Sadanandan; Lincy Mathew; Nitish Naik; Anup Banerji; S.M. Ashraf; P.K. Asokan; Bishwa Bhushan Bharti; Biswajit Majumder; Dhiman Kahali; Dhurjati Prasad Sinha; Dipak Sharma; Dipankar Ghosh Dastidar; Dipankar Mukhapdhyay; Gurpreet Sing Wander; Harinder Kumar Bali; B. Kesavamoorthy; Manoj Kumar Agarwala; Narendra Nath Khanna; B.H. Natesh; Pravin K. Goel; Rabindra Nath Chakraborty; Rajendra Kumar Jain; Rakesh Yadav; L. Sameer Dani; Satyavan Sharma; Satyendra Tewari; K.K. Sethi; Sharad Chandra; Subrato Mandal; Suman Bhandari; Sundandan Sikdar; Vivek Gupta; Pratap Chandra Rath; Vijay Harikisan Bang; Debabrata Roy; Mrinal Kanti Das; Partho Sarathi Banerjee
Source
Indian Heart Journal, Vol 75, Iss 4, Pp 243-250 (2023)
Subject
Language
English
ISSN
0019-4832
Abstract
Objective: To find out differences in the presentation, management and outcomes of COVID-19 infected STEMI patients compared to age and sex-matched non-infected STEMI patients treated during the same period. Methods: This was a retrospective multicentre observational registry in which we collected data of COVID-19 positive STEMI patients from selected tertiary care hospitals across India. For every COVID-19 positive STEMI patient, two age and sex-matched COVID-19 negative STEMI patients were enrolled as control. The primary endpoint was a composite of in-hospital mortality, re-infarction, heart failure, and stroke. Results: 410 COVID-19 positive STEMI cases were compared with 799 COVID-19 negative STEMI cases. The composite of death/reinfarction/stroke/heart failure was significantly higher among the COVID-19 positive STEMI patients compared with COVID-19 negative STEMI cases (27.1% vs 20.7% p value = 0.01); though mortality rate did not differ significantly (8.0% vs 5.8% p value = 0.13). Significantly lower proportion of COVID-19 positive STEMI patients received reperfusion treatment and primary PCI (60.7% vs 71.1% p value=< 0.001 and 15.4% vs 23.4% p value = 0.001 respectively). Rate of systematic early PCI (pharmaco-invasive treatment) was significantly lower in the COVID-19 positive group compared with COVID-19 negative group. There was no difference in the prevalence of high thrombus burden (14.5% and 12.0% p value = 0.55 among COVID-19 positive and negative patients respectively) Conclusions: In this large registry of STEMI patients, we did not find significant excess in in-hospital mortality among COVID-19 co-infected patients compared with non-infected patients despite lower rate of primary PCI and reperfusion treatment, though composite of in-hospital mortality, re-infarction, stroke and heart failure was higher.