학술논문
Unfavorable impact of cancer cachexia on activity of daily living and need for inpatient care in elderly patients with advanced non-small-cell lung cancer in Japan: a prospective longitudinal observational study
Document Type
article
Author
Tateaki Naito; Taro Okayama; Takashi Aoyama; Takuya Ohashi; Yoshiyuki Masuda; Madoka Kimura; Hitomi Shiozaki; Haruyasu Murakami; Hirotsugu Kenmotsu; Tetsuhiko Taira; Akira Ono; Kazushige Wakuda; Hisao Imai; Takuya Oyakawa; Takeshi Ishii; Shota Omori; Kazuhisa Nakashima; Masahiro Endo; Katsuhiro Omae; Keita Mori; Nobuyuki Yamamoto; Akira Tanuma; Toshiaki Takahashi
Source
BMC Cancer, Vol 17, Iss 1, Pp 1-10 (2017)
Subject
Language
English
ISSN
1471-2407
Abstract
Abstract Background Cancer cachexia in elderly patients may substantially impact physical function and medical dependency. The aim of this study was to estimate the impact of cachexia on activity of daily living (ADL), length of hospital stay, and inpatient medical costs among elderly patients with advanced non-small-cell lung cancer (NSCLC) receiving chemotherapy. Methods Thirty patients aged ≥70 years with advanced NSCLC (stage III-IV) scheduled to receive first-line chemotherapy were prospectively enrolled between January 2013 and November 2014. ADL was assessed using the Barthel index. The disability-free survival time (DFS) was calculated as the time between the date of study entry and the date of onset of a disabling event, which was defined as a 10-point decrease in the Barthel index from that at baseline. The mean cumulative function of the length of hospital stay and inpatient medical costs (¥, Japanese yen) was calculated. Results The study patients comprised 11 women and 19 men, with a median age of 74 (range, 70–82) years. Cachexia was diagnosed in 19 (63%) patients. Cachectic patients had a shorter DFS (7.5 vs. 17.1 months, p