학술논문
Spirometric phenotypes from early childhood to young adulthood: a Chronic Airway Disease Early Stratification study
Document Type
article
Author
Gang Wang; Jenny Hallberg; Dimitrios Charalampopoulos; Maribel Casas Sanahuja; Robab Breyer-Kohansal; Arnulf Langhammer; Raquel Granell; Judith M. Vonk; Annemiek Mian; Núria Olvera; Lisbeth Mølgaard Laustsen; Eva Rönmark; Alicia Abellan; Alvar Agusti; Syed Hasan Arshad; Anna Bergström; H. Marike Boezen; Marie-Kathrin Breyer; Otto Burghuber; Anneli Clea Bolund; Adnan Custovic; Graham Devereux; Gavin C. Donaldson; Liesbeth Duijts; Ana Esplugues; Rosa Faner; Ferran Ballester; Judith Garcia-Aymerich; Ulrike Gehring; Sadia Haider; Sylvia Hartl; Helena Backman; John W. Holloway; Gerard H. Koppelman; Aitana Lertxundi; Turid Lingaas Holmen; Lesley Lowe; Sara M. Mensink-Bout; Clare S. Murray; Graham Roberts; Linnea Hedman; Vivi Schlünssen; Torben Sigsgaard; Angela Simpson; Jordi Sunyer; Maties Torrent; Stephen Turner; Maarten Van den Berge; Roel C.H. Vermeulen; Sigrid Anna Aalberg Vikjord; Jadwiga A. Wedzicha; Anke H. Maitland van der Zee; Erik Melén
Source
ERJ Open Research, Vol 7, Iss 4 (2021)
Subject
Language
English
ISSN
2312-0541
23120541
23120541
Abstract
Background The prevalences of obstructive and restrictive spirometric phenotypes, and their relation to early-life risk factors from childhood to young adulthood remain poorly understood. The aim was to explore these phenotypes and associations with well-known respiratory risk factors across ages and populations in European cohorts. Methods We studied 49 334 participants from 14 population-based cohorts in different age groups (≤10, >10–15, >15–20, >20–25 years, and overall, 5–25 years). The obstructive phenotype was defined as forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) z-score less than the lower limit of normal (LLN), whereas the restrictive phenotype was defined as FEV1/FVC z-score ≥LLN, and FVC z-score