학술논문
Long-term antiretroviral therapy initiated in acute HIV infection prevents residual dysfunction of HIV-specific CD8+ T cells
Document Type
article
Author
Hiroshi Takata; Juyeon C. Kakazu; Julie L. Mitchell; Eugene Kroon; Donn J. Colby; Carlo Sacdalan; Hongjun Bai; Philip K. Ehrenberg; Aviva Geretz; Supranee Buranapraditkun; Suteeraporn Pinyakorn; Jintana Intasan; Somporn Tipsuk; Duanghathai Suttichom; Peeriya Prueksakaew; Thep Chalermchai; Nitiya Chomchey; Nittaya Phanuphak; Mark de Souza; Nelson L. Michael; Merlin L. Robb; Elias K. Haddad; Trevor A Crowell; Sandhya Vasan; Victor G. Valcour; Daniel C. Douek; Rasmi Thomas; Morgane Rolland; Nicolas Chomont; Jintanat Ananworanich; Lydie Trautmann; Nipat Teeratakulpisarn; Supanit Pattanachaiwit; Somchai Sriplienchan; Ponpen Tantivitayakul; Ratchapong Kanaprach; Kiat Ruxrungtham; Netsiri Dumrongpisutikul; Ponlapat Rojnuckarin; Suthat Chottanapund; Kultida Poltavee; Tassanee Luekasemsuk; Hathairat Savadsuk; Suwanna Puttamsawin; Khunthalee Benjapornpong; Nisakorn Ratnaratorn; Kamonkan Tangnaree; Chutharat Munkong; Rommanus Thaimanee; Patcharin Eamyoung; Sasiwimol Ubolyam; Sukalya Lerdlum; Sopark Manasnayakorn; Rugsun Rerknimitr; Sunee Sirivichayakul; Phandee Wattanaboonyongcharoen; Jessica Cowden; Alexandra Schuetz; Siriwat Akapirat; Nampueng Churikanont; Saowanit Getchalarat; Denise Hsu; Ellen Turk; Oratai Butterworth; Mark Milazzo; Leigh Anne Eller; Julie Ake; Serena Spudich; CAPT Lawrence Fox; Silvia Ratto-Kim; Victor DeGruttola; Yotin Chinvarun; Pasiri Sithinamsuwan; James Fletcher; Bruce Shiramizu
Source
EBioMedicine, Vol 84, Iss , Pp 104253- (2022)
Subject
Language
English
ISSN
2352-3964
Abstract
Summary: Background: Harnessing CD8+ T cell responses is being explored to achieve HIV remission. Although HIV-specific CD8+ T cells become dysfunctional without treatment, antiretroviral therapy (ART) partially restores their function. However, the extent of this recovery under long-term ART is less understood. Methods: We analyzed the differentiation status and function of HIV-specific CD8+ T cells after long-term ART initiated in acute or chronic HIV infection ex vivo and upon in vitro recall. Findings: ART initiation in any stage of acute HIV infection promoted the persistence of long-lived HIV-specific CD8+ T cells with high expansion (P