학술논문
Mortality and cardiovascular and respiratory morbidity in individuals with impaired FEV1 (PURE): an international, community-based cohort study
Document Type
article
Author
MyLinh Duong, MBBS; Shofiqul Islam, PhD; Sumathy Rangarajan, MSc; Darryl Leong, PhD; Om Kurmi, PhD; Koon Teo, ProfMB; Kieran Killian, PhD; Gilles Dagenais, ProfMD; Scott Lear, ProfPhD; Andreas Wielgosz, ProfMD; Sanjeev Nair, ProfMD; Viswanathan Mohan, MD; Prem Mony, MD; Rajeev Gupta, ProfMD; Rajesh Kumar, ProfMD; Omar Rahman, ProfDSc; Khalid Yusoff, ProfMBBS; Johannes Lodewykus du Plessis, ProfPhD; Ehimario U Igumbor, PhD; Jephat Chifamba, DPhil; Wei Li, ProfPhD; Yin Lu, PhD; Fumin Zhi, BSc; Ruohua Yan, MSc; Romaina Iqbal, PhD; Noorhassim Ismail, ProfMD; Katarzyna Zatonska, MD; Kubilay Karsidag, ProfMD; Annika Rosengren, ProfMD; Ahmad Bahonar, MD; Afazalhussein Yusufali, MD; Pablo M Lamelas, MD; Alvaro Avezum, ProfMD; Patricio Lopez-Jaramillo, ProfMD; Fernando Lanas, ProfMD; Paul M O'Byrne, ProfMB; Salim Yusuf, ProfDPhil
Source
The Lancet Global Health, Vol 7, Iss 5, Pp e613-e623 (2019)
Subject
Language
English
ISSN
2214-109X
Abstract
Summary: Background: The associations between the extent of forced expiratory volume in 1 s (FEV1) impairment and mortality, incident cardiovascular disease, and respiratory hospitalisations are unclear, and how these associations might vary across populations is unknown. Methods: In this international, community-based cohort study, we prospectively enrolled adults aged 35–70 years who had no intention of moving residences for 4 years from rural and urban communities across 17 countries. A portable spirometer was used to assess FEV1. FEV1 values were standardised within countries for height, age, and sex, and expressed as a percentage of the country-specific predicted FEV1 value (FEV1%). FEV1% was categorised as no impairment (FEV1% ≥0 SD from country-specific mean), mild impairment (FEV1%