학술논문
Association Between Whole Blood–Derived Mitochondrial DNA Copy Number, Low‐Density Lipoprotein Cholesterol, and Cardiovascular Disease Risk
Document Type
article
Author
Xue Liu; Xianbang Sun; Yuankai Zhang; Wenqing Jiang; Meng Lai; Kerri L. Wiggins; Laura M. Raffield; Lawrence F. Bielak; Wei Zhao; Achilleas Pitsillides; Jeffrey Haessler; Yinan Zheng; Thomas W. Blackwell; Jie Yao; Xiuqing Guo; Yong Qian; Bharat Thyagarajan; Nathan Pankratz; Stephen S. Rich; Kent D. Taylor; Patricia A. Peyser; Susan R. Heckbert; Sudha Seshadri; Eric Boerwinkle; Megan L. Grove; Nicholas B. Larson; Jennifer A. Smith; Ramachandran S. Vasan; Annette L. Fitzpatrick; Myriam Fornage; Jun Ding; April P. Carson; Goncalo Abecasis; Josée Dupuis; Alexander Reiner; Charles Kooperberg; Lifang Hou; Bruce M. Psaty; James G. Wilson; Daniel Levy; Jerome I. Rotter; Joshua C. Bis; Claudia L. Satizabal; Dan E. Arking; Chunyu Liu
Source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 20 (2023)
Subject
Language
English
ISSN
2047-9980
Abstract
Background The relationship between mitochondrial DNA copy number (mtDNA CN) and cardiovascular disease remains elusive. Methods and Results We performed cross‐sectional and prospective association analyses of blood‐derived mtDNA CN and cardiovascular disease outcomes in 27 316 participants in 8 cohorts of multiple racial and ethnic groups with whole‐genome sequencing. We also performed Mendelian randomization to explore causal relationships of mtDNA CN with coronary heart disease (CHD) and cardiometabolic risk factors (obesity, diabetes, hypertension, and hyperlipidemia). P