학술논문
Mapping molecular subtype specific alterations in breast cancer brain metastases identifies clinically relevant vulnerabilities
Document Type
article
Author
Nicola Cosgrove; Damir Varešlija; Stephen Keelan; Ashuvinee Elangovan; Jennifer M. Atkinson; Sinéad Cocchiglia; Fiona T. Bane; Vikrant Singh; Simon Furney; Chunling Hu; Jodi M. Carter; Steven N. Hart; Siddhartha Yadav; Matthew P. Goetz; Arnold D. K. Hill; Steffi Oesterreich; Adrian V. Lee; Fergus J. Couch; Leonie S. Young
Source
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
The molecular landscape of breast cancer brain metastases (BCBM) is still understudied, especially for different breast cancer subtypes. Here, the authors characterise subtype-specific BCBMs using genomics and transcriptomics and identify homologous recombination deficiency as a key therapeutic vulnerability.