학술논문
Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts
Document Type
article
Author
Rebecca E. Graff; Taylor B. Cavazos; Khanh K. Thai; Linda Kachuri; Sara R. Rashkin; Joshua D. Hoffman; Stacey E. Alexeeff; Maruta Blatchins; Travis J. Meyers; Lancelote Leong; Caroline G. Tai; Nima C. Emami; Douglas A. Corley; Lawrence H. Kushi; Elad Ziv; Stephen K. Van Den Eeden; Eric Jorgenson; Thomas J. Hoffmann; Laurel A. Habel; John S. Witte; Lori C. Sakoda
Source
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
While genetic loci shared between cancer types have been identified, cross-cancer relationships for polygenic risk scores have not been well studied. Here, the authors have developed polygenic risk scores for 16 cancers in two large cohorts and identified positive and inverse cross-cancer associations.