학술논문
The genetic regulatory signature of type 2 diabetes in human skeletal muscle
Document Type
article
Author
Laura J. Scott; Michael R. Erdos; Jeroen R. Huyghe; Ryan P. Welch; Andrew T. Beck; Brooke N. Wolford; Peter S. Chines; John P. Didion; Narisu Narisu; Heather M. Stringham; D. Leland Taylor; Anne U. Jackson; Swarooparani Vadlamudi; Lori L. Bonnycastle; Leena Kinnunen; Jouko Saramies; Jouko Sundvall; Ricardo D'Oliveira Albanus; Anna Kiseleva; John Hensley; Gregory E. Crawford; Hui Jiang; Xiaoquan Wen; Richard M. Watanabe; Timo A. Lakka; Karen L. Mohlke; Markku Laakso; Jaakko Tuomilehto; Heikki A. Koistinen; Michael Boehnke; Francis S. Collins; Stephen C. J. Parker
Source
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Subject
Language
English
ISSN
2041-1723
Abstract
More than 90% of genetic variants associated with type 2 diabetes occur in non-coding regions. Scott et al. report genomes, epigenomes and transcriptomes of skeletal muscle from 271 participants with a range of glucose tolerances, revealing a genetic regulatory architecture enriched in muscle stretch/super enhancers.