학술논문
Serum HCoV-spike specific antibodies do not protect against subsequent SARS-CoV-2 infection in children and adolescents
Document Type
article
Author
Helen Ratcliffe; Karen S. Tiley; Stephanie Longet; Claire Tonry; Cathal Roarty; Chris Watson; Gayatri Amirthalingam; Iason Vichos; Ella Morey; Naomi L. Douglas; Spyridoula Marinou; Emma Plested; Parvinder K. Aley; Eva Galiza; Saul N. Faust; Stephen Hughes; Clare Murray; Marion R. Roderick; Fiona Shackley; Sam Oddie; Tim W.R. Lee; David P.J. Turner; Mala Raman; Stephen Owens; Paul J. Turner; Helen Cockerill; Jamie Lopez Bernal; Samreen Ijaz; John Poh; Justin Shute; Ezra Linley; Ray Borrow; Katja Hoschler; Kevin E. Brown; Miles W. Carroll; Paul Klenerman; Susanna J. Dunachie; Mary Ramsay; Merryn Voysey; Thomas Waterfield; Matthew D. Snape
Source
iScience, Vol 26, Iss 12, Pp 108500- (2023)
Subject
Language
English
ISSN
2589-0042
Abstract
Summary: SARS-CoV-2 infections in children are generally asymptomatic or mild and rarely progress to severe disease and hospitalization. Why this is so remains unclear. Here we explore the potential for protection due to pre-existing cross-reactive seasonal coronavirus antibodies and compare the rate of antibody decline for nucleocapsid and spike protein in serum and oral fluid against SARS-CoV-2 within the pediatric population. No differences in seasonal coronaviruses antibody concentrations were found at baseline between cases and controls, suggesting no protective effect from pre-existing immunity against seasonal coronaviruses. Antibodies against seasonal betacoronaviruses were boosted in response to SARS-CoV-2 infection. In serum, anti-nucleocapsid antibodies fell below the threshold of positivity more quickly than anti-spike protein antibodies. These findings add to our understanding of protection against infection with SARS-CoV-2 within the pediatric population, which is important when considering pediatric SARS-CoV-2 immunization policies.