학술논문
Maternal and pregnancy related predictors of cardiometabolic traits in newborns.
Document Type
article
Author
Katherine M Morrison; Sonia S Anand; Salim Yusuf; Stephanie A Atkinson; Karleen M Schulze; Purnima Rao-Melacini; Matthew J McQueen; Sarah McDonald; Richard Persadie; Barry Hunter; Jacqueline Bourgeois; Jan W Jansen; Koon K Teo; FAMILY (Family Atherosclerosis Monitoring In earLY Life) Study investigators
Source
PLoS ONE, Vol 8, Iss 2, p e55815 (2013)
Subject
Language
English
ISSN
1932-6203
Abstract
BACKGROUND: The influence of multiple maternal and pregnancy characteristics on offspring cardiometabolic traits at birth is not well understood and was evaluated in this study. METHODS AND FINDINGS: The Family Atherosclerosis Monitoring In earLY life (FAMILY) Study prospectively evaluated 11 cardiometabolic traits in 901 babies born to 857 mothers. The influence of maternal age, health (pre-pregnancy weight, blood pressure, glycemic status, lipids), health behaviors (diet, activity, smoking) and pregnancy characteristics (gestational age at birth, gestational weight gain and placental-fetal ratio) were examined. Greater gestational age influenced multiple newborn cardiometabolic traits including cord blood lipids, glucose and insulin, body fat and blood pressure. In a subset of 442 singleton mother/infant pairs, principal component analysis grouped 11 newborn cardiometabolic traits into 5 components (anthropometry/insulin, 2 lipid components, blood pressure and glycemia), accounting for 74% of the variance of the 11 outcome variables. Determinants of these components, corrected for sex and gestational age, were examined. Baby anthropometry/insulin was independently predicted by higher maternal pre-pregnancy weight (standardized estimate 0.30) and gestational weight gain (0.30; both p