학술논문
Plasma β‐synuclein, GFAP, and neurofilaments in patients with malignant gliomas undergoing surgical and adjuvant therapy
Document Type
article
Author
Source
Annals of Clinical and Translational Neurology, Vol 10, Iss 10, Pp 1924-1930 (2023)
Subject
Language
English
ISSN
2328-9503
Abstract
Abstract We analyzed the longitudinal concentrations and prognostic roles of plasma β‐synuclein (β‐syn), glial fibrillary acidic protein (GFAP), and neurofilament proteins (NfL and NfH) in 33 patients with malignant gliomas, who underwent surgical and adjuvant therapy. GFAP and NfL levels were increased in patients with glioblastoma compared to cases with other tumors. β‐syn, NfL and NfH increased after surgery, whereas GFAP decreased at long‐term follow‐up. β‐syn and neurofilament concentrations were influenced by surgery and/or radiotherapy regimens. GFAP and neurofilament levels were significantly associated with survival. Plasma neuronal and astrocytic biomarkers are differentially altered in malignant glioma types and displayed distinct trajectories after surgical and adjuvant therapy.