학술논문
The prognostic value of the previous nephrectomy in pretreated metastatic renal cell carcinoma receiving immunotherapy: a sub-analysis of the Meet-URO 15 study
Document Type
article
Author
Sara Elena Rebuzzi; Alessio Signori; Giuseppe Luigi Banna; Annalice Gandini; Giuseppe Fornarini; Alessandra Damassi; Marco Maruzzo; Ugo De Giorgi; Umberto Basso; Silvia Chiellino; Luca Galli; Paolo Andrea Zucali; Emanuela Fantinel; Emanuele Naglieri; Giuseppe Procopio; Michele Milella; Francesco Boccardo; Lucia Fratino; Stefania Pipitone; Riccardo Ricotta; Stefano Panni; Veronica Mollica; Mariella Sorarù; Matteo Santoni; Alessio Cortellini; Veronica Prati; Hector Josè Soto Parra; Daniele Santini; Francesco Atzori; Marilena Di Napoli; Orazio Caffo; Marco Messina; Franco Morelli; Giuseppe Prati; Franco Nolè; Francesca Vignani; Alessia Cavo; Giandomenico Roviello; Pasquale Rescigno; Sebastiano Buti
Source
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-7 (2022)
Subject
Language
English
ISSN
1479-5876
Abstract
Abstract Background Nephrectomy is considered the backbone of managing patients with localized and selected metastatic renal cell carcinoma (mRCC). The prognostic role of nephrectomy has been widely investigated with cytokines and targeted therapy, but it is still unclear in the immunotherapy era. Methods We investigated the Meet-URO-15 study dataset of 571 pretreated mRCC patients receiving nivolumab as second or further lines about the prognostic role of the previous nephrectomy (received in either the localized or metastatic setting) in the overall population and according to the Meet-URO score groups. Results Patients who underwent nephrectomy showed a significantly reduced risk of death (HR 0.44, 95% CI 0.32–0.60, p