학술논문
Spatial oxidation of L-plastin downmodulates actin-based functions of tumor cells
Document Type
article
Author
Source
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
The actin-remodelling protein L-plastin promotes tumour migration and invasion. Here, the authors show that L-plastin is regulated spatially by ROS-induced thiol oxidation which inhibits its actin-bundling function and cell spreading and filopodial extension formation in tumor cells.