학술논문
The Hemophilia Joint Health Score version 2.1 Validation in Adult Patients Study: A multicenter international study
Document Type
article
Author
Jean St‐Louis; Audrey Abad; Sharon Funk; Merlyn Tilak; Stephen Classey; Nichan Zourikian; Paul McLaughlin; Sébastien Lobet; Grace Hernandez; Stacie Akins; Anna J. Wells; Marilyn Manco‐Johnson; Judy John; Steve Austin; Pratima Chowdary; Cedric Hermans; Diane Nugent; Nihal Bakeer; Sarah Mangles; Pamela Hilliard; Victor S. Blanchette; Brian M. Feldman
Source
Research and Practice in Thrombosis and Haemostasis, Vol 6, Iss 2, Pp n/a-n/a (2022)
Subject
Language
English
ISSN
2475-0379
Abstract
Abstract Background The Hemophilia Joint Health Score (HJHS) was developed and validated to detect arthropathy in children. Additional evidence is required to show validity in adults. We studied the convergent and discriminant construct validity of the HJHS version 2.1(HJHSv2.1) in adults with hemophilia. A secondary aim was to define age‐related normative adult HJHSv2.1 reference values. Methods We studied 192 adults with hemophilia, and 120 healthy adults in four age‐matched groups—18 to 29, 30 to 40, 41 to 50, and >50 years—at nine centers. Trained physiotherapists scored the HJHS and World Federation of Hemophilia (WFH) joint score. Health history, the Functional Independence Scale of Hemophilia (FISH), Hemophilia Activities List (HAL), and Short‐Form McGill Pain Questionnaire (SF‐MPQ) were also collected. Results The median age was 35.0 years. Of participants with hemophilia, 68% had severe, 14% moderate, and 18% mild disease. The HJHS correlated strongly with WFH score (Spearman’s rho [rs] = .95, P