학술논문
Human preprocalcitonin self-antigen generates TAP-dependent and -independent epitopes triggering optimised T-cell responses toward immune-escaped tumours
Document Type
article
Author
Aurélie Durgeau; Yasemin Virk; Gwendoline Gros; Elodie Voilin; Stéphanie Corgnac; Fayçal Djenidi; Jérôme Salmon; Julien Adam; Vincent de Montpréville; Pierre Validire; Soldano Ferrone; Salem Chouaib; Alexander Eggermont; Jean-Charles Soria; François Lemonnier; Eric Tartour; Nathalie Chaput; Benjamin Besse; Fathia Mami-Chouaib
Source
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
Tumours can escape CD8 T-cell immunity by down-regulating antigen presentation machinery components, such as TAP. Here the authors describe tumour antigenic peptides processed by TAP-independent and -dependent pathways and show in mouse models that these peptides can be exploited to induce antitumor T-cell activity when TAP expression is downregulated.