학술논문
The Apaf-1 apoptosome induces formation of caspase-9 homo- and heterodimers with distinct activities
Document Type
article
Author
Source
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Subject
Language
English
ISSN
2041-1723
Abstract
Apoptotic initiator caspases are thought to be activated through homodimerization but this remains controversial. Here the authors demonstrate that caspase-9 can adopt two distinct conformations within the Apaf-1 apoptosome, each with distinct properties that contribute to the overall function of the complex.