학술논문
Obstructive sleep apnea is associated with impaired renal function in patients with diabetic kidney disease
Document Type
article
Author
Ester Zamarrón; Ana Jaureguizar; Aldara García-Sánchez; Trinidad Díaz-Cambriles; Alberto Alonso-Fernández; Vanesa Lores; Olga Mediano; Paula Rodríguez-Rodríguez; Sheila Cabello-Pelegrín; Enrique Morales-Ruíz; María T. Ramírez-Prieto; María Isabel Valiente-Díaz; Teresa Gómez-García; Francisco García-Río; Spanish Sleep Network
Source
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Subject
Language
English
ISSN
2045-2322
Abstract
Abstract Obstructive sleep apnea (OSA) is a recognized risk factor for the development of diabetic kidney disease (DKD). Our objectives were to compare the urinary albumin–creatinine ratio (UACR) and estimated glomerular filtration rate (eGFR) of patients with DKD according to OSA severity, and to evaluate the contribution of sleep parameters to their renal function. In a multicenter, observational, cross-sectional study, 214 patients with DKD were recruited. After a sleep study, UACR and eGFR were measured, as well as serum creatinine, fasting glucose, glycated hemoglobin, insulin resistance, lipid profile and C-reactive protein. UACR was higher in severe OSA patients (920 ± 1053 mg/g) than in moderate (195 ± 232 mg/g, p