학술논문
Immune cell profiles of patients with interstitial cystitis/bladder pain syndrome
Document Type
article
Author
Source
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-9 (2022)
Subject
Language
English
ISSN
1479-5876
Abstract
Abstract Interstitial cystitis/bladder pain syndrome (IC/BPS) is a disorder characterized by bladder pain upon filling which severely affects quality of life. Clinical presentation can vary. Local inflammatory events typify the clinical presentation of IC/BPS patients with Hunner lesions (IC/BPS-HL). It has previously been proposed that B cells are more prevalent in HL, but understanding their exact role in this environment requires a more complete immunological profile of HL. We characterized immunological dysfunction specifically in HL using immunohistochemistry. We detected significantly more plasma cells (50× increase, p