학술논문
Sex-specific and pleiotropic effects underlying kidney function identified from GWAS meta-analysis
Document Type
article
Author
Sarah E. Graham; Jonas B. Nielsen; Matthew Zawistowski; Wei Zhou; Lars G. Fritsche; Maiken E. Gabrielsen; Anne Heidi Skogholt; Ida Surakka; Whitney E. Hornsby; Damian Fermin; Daniel B. Larach; Sachin Kheterpal; Chad M. Brummett; Seunggeun Lee; Hyun Min Kang; Goncalo R. Abecasis; Solfrid Romundstad; Stein Hallan; Matthew G. Sampson; Kristian Hveem; Cristen J. Willer
Source
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
Estimated glomerular filtration rate (eGFR) is a measure of kidney function and used to characterize chronic kidney disease. Here, Graham et al. identify 53 novel loci for eGFR in a GWAS meta-analysis, a subset of which are associated with other common diseases, such as diabetes and hypertension, based on PheWAS.