학술논문
Sequence variation at ANAPC1 accounts for 24% of the variability in corneal endothelial cell density
Document Type
article
Author
Erna V. Ivarsdottir; Stefania Benonisdottir; Gudmar Thorleifsson; Patrick Sulem; Asmundur Oddsson; Unnur Styrkarsdottir; Snaedis Kristmundsdottir; Gudny A. Arnadottir; Gudmundur Thorgeirsson; Ingileif Jonsdottir; Gunnar M. Zoega; Unnur Thorsteinsdottir; Daniel F. Gudbjartsson; Fridbert Jonasson; Hilma Holm; Kari Stefansson
Source
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
The corneal endothelium is crucial for proper vision. Here, Ivarsdottir et al. perform genome-wide association studies for various corneal endothelial cell measurements and find that an intergenic variant near ANAPC1 explains 24% of the variance of endothelial cell density and associates with corneal hysteresis.