학술논문
A genome-wide association study for survival from a multi-centre European study identified variants associated with COVID-19 risk of death
Document Type
article
Author
Francesca Minnai; Filippo Biscarini; Martina Esposito; Tommaso A. Dragani; Luis Bujanda; Souad Rahmouni; Marta E. Alarcón-Riquelme; David Bernardo; Elena Carnero-Montoro; Maria Buti; Hugo Zeberg; Rosanna Asselta; Manuel Romero-Gómez; GEN-COVID Multicenter Study; Israel Fernandez-Cadenas; Chiara Fallerini; Kristina Zguro; Susanna Croci; Margherita Baldassarri; Mirella Bruttini; Simone Furini; Alessandra Renieri; Francesca Colombo
Source
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Subject
Language
English
ISSN
2045-2322
Abstract
Abstract The clinical manifestations of SARS-CoV-2 infection vary widely among patients, from asymptomatic to life-threatening. Host genetics is one of the factors that contributes to this variability as previously reported by the COVID-19 Host Genetics Initiative (HGI), which identified sixteen loci associated with COVID-19 severity. Herein, we investigated the genetic determinants of COVID-19 mortality, by performing a case-only genome-wide survival analysis, 60 days after infection, of 3904 COVID-19 patients from the GEN-COVID and other European series (EGAS00001005304 study of the COVID-19 HGI). Using imputed genotype data, we carried out a survival analysis using the Cox model adjusted for age, age2, sex, series, time of infection, and the first ten principal components. We observed a genome-wide significant (P-value