학술논문
Increased DNA methylation variability in type 1 diabetes across three immune effector cell types
Document Type
article
Author
Dirk S. Paul; Andrew E. Teschendorff; Mary A.N. Dang; Robert Lowe; Mohammed I. Hawa; Simone Ecker; Huriya Beyan; Stephanie Cunningham; Alexandra R. Fouts; Anita Ramelius; Frances Burden; Samantha Farrow; Sophia Rowlston; Karola Rehnstrom; Mattia Frontini; Kate Downes; Stephan Busche; Warren A. Cheung; Bing Ge; Marie-Michelle Simon; David Bujold; Tony Kwan; Guillaume Bourque; Avik Datta; Ernesto Lowy; Laura Clarke; Paul Flicek; Emanuele Libertini; Simon Heath; Marta Gut; Ivo G Gut; Willem H. Ouwehand; Tomi Pastinen; Nicole Soranzo; Sabine E. Hofer; Beate Karges; Thomas Meissner; Bernhard O. Boehm; Corrado Cilio; Helena Elding Larsson; Åke Lernmark; Andrea K. Steck; Vardhman K. Rakyan; Stephan Beck; R. David Leslie
Source
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Subject
Language
English
ISSN
2041-1723
Abstract
The incidence of type 1 diabetes is increasing, potentially implicating non-genetic factors. Here the authors conduct an epigenome-wide association study in disease-discordant twins and find increased DNA methylation variability at genes associated with immune cell metabolism and the cell cycle.