학술논문
Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion
Document Type
article
Author
Silvia Martinelli; Elmira A. Anderzhanova; Thomas Bajaj; Svenja Wiechmann; Frederik Dethloff; Katja Weckmann; Daniel E. Heinz; Tim Ebert; Jakob Hartmann; Thomas M. Geiger; Michael Döngi; Kathrin Hafner; Max L. Pöhlmann; Lee Jollans; Alexandra Philipsen; Susanne V. Schmidt; Ulrike Schmidt; Giuseppina Maccarrone; Valentin Stein; Felix Hausch; Christoph W. Turck; Mathias V. Schmidt; Anne-Kathrin Gellner; Bernhard Kuster; Nils C. Gassen
Source
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Glucocorticoids are associated with stress. Here, the authors show that high levels of glucocorticoid stress promote secretory autophagy of matrix metalloproteinase 9 via a stress responsive chaperone, increasing brain-derived neurotrophic factor processing and potentially altering adult synaptic plasticity.